Cheesy Chicken Spaghetti Casserole Recipe

There’s something special about recipes that bring people together. A few years ago, a friend and I were planning a casual dinner, and we wanted something hearty, easy, and packed with flavor. She mentioned a cheesy spaghetti casserole her grandmother used to make, and we decided to give it a try—tweaking it along the way to suit our tastes. 

What started as a simple meal turned into an instant favorite. The creamy, cheesy sauce, the tender chicken, and the slight kick from the tomatoes with green chilies created a dish that everyone kept coming back for. Now, it’s my go-to comfort meal, perfect for feeding a hungry family or making any gathering feel extra cozy!

Why You’ll Love This Chicken Spaghetti

• Creamy
• Easy
• Family-friendly
• Cheesy 

Chicken Spaghetti Casserole Recipe

For this delicious chicken spaghetti bake, you’ll need the following ingredients:

Ingredients

• 16 ounces of spaghetti – The base of this dish, cooked to al dente so it holds up well in the casserole.
• 1.5 lbs shredded chicken – A great way to use up rotisserie or leftover chicken for added convenience.
• 3/4 cup cheddar cheese – Adds a sharp, tangy flavor that complements the creamy sauce.
• 1 teaspoon onion powder – Enhances the overall savory flavor without needing fresh onions.
• 1 teaspoon garlic powder – Brings a warm, aromatic depth to the casserole.
• 8 ounces cream cheese – Creates a velvety, creamy texture in the sauce.
• 10 1/2 ounces cream of chicken soup – Adds creaminess and a rich, savory chicken flavor.
• 10 1/2 ounces cream of mushroom soup – A classic casserole ingredient that adds depth and umami.
• 10 ounces diced Rotel tomatoes with green chilies – Provides a slight kick and some acidity to balance the richness.
• 16 ounces processed cheese – Melts beautifully for that ultra-creamy consistency.
• 1/3 cup milk – Helps thin out the sauce for a smooth consistency.
• Salt and Pepper to taste – Balances and enhances all the flavors

Optional Add-Ons

• Chopped bell peppers or mushrooms – For added texture and flavor.
• Bacon bits – A smoky, crispy addition.
• Jalapeños – If you love a spicy kick.
• Breadcrumbs or crushed crackers – For a crunchy topping.

Tools You’ll Need

• Large pot
• Mixing bowls
• Baking dish (9×13-inch).
• Wooden spoon or spatula
• Cheese grater

Step-by-Step Instructions

Step 1. Cook the Spaghetti

Bring a large pot of salted water to a boil. Add the spaghetti and cook according to the package instructions until al dente. Drain the pasta, rinse it with warm water to remove excess starch, and set it aside. Rinsing prevents it from becoming too sticky when combined with the sauce.

Step 2. Prepare the Sauce

In a large mixing bowl, combine the softened cream cheese, cream of chicken soup, cream of mushroom soup, milk, onion powder, garlic powder, and diced tomatoes with green chilies. Stir everything together until the mixture is smooth and fully blended. If needed, use a whisk to break up the cream cheese for an even consistency.

Step 3. Add the Chicken and Cheese

Stir in the shredded chicken, half of the cheddar cheese, and half of the processed cheese into the sauce. Make sure the chicken is evenly coated so that every bite is flavorful. The cheese will start to soften, creating a creamy base that binds the ingredients together.

Step 4. Combine with Spaghetti

Gradually add the cooked spaghetti to the sauce mixture, using tongs or a large spoon to gently fold everything together. Ensure that every strand of pasta is evenly coated with the rich, cheesy sauce.

Step 5. Assemble the Casserole

Grease a 9×13-inch baking dish with cooking spray or butter to prevent sticking. Pour the spaghetti mixture into the dish, spreading it out evenly. Sprinkle the remaining cheddar and processed cheese over the top, ensuring full coverage for that golden, cheesy crust.

Step 6. Bake to Perfection

Preheat your oven to 350°F (175°C). Place the baking dish on the middle rack and bake uncovered for 25-30 minutes, or until the cheese is fully melted and bubbly. If you want a slight golden crust, broil the casserole for the last 2-3 minutes.

Step 7. Serve and Enjoy

Let the casserole rest for about 5 minutes before serving. This helps the cheese set slightly, making it easier to scoop out portions without losing its creamy texture. Serve warm and enjoy!

Best Paired With

• A fresh green salad – To balance out the richness.
• Garlic bread – For an extra indulgent meal.
• Steamed veggies – Such as broccoli or green beans for added nutrition.

Storage and Serving

• Refrigerate: Store leftovers in an airtight container for up to 4 days.
• Freeze: Freeze in a freezer-safe dish for up to 3 months. Thaw in the fridge overnight before reheating.
• Reheat: Warm in the oven at 350°F for 15-20 minutes or microwave in short intervals.

Tips for Success

• Don’t overcook the pasta; it will continue to soften as it bakes.
• Use a block of cheese and shred it yourself for the best meltability.
• Let the casserole rest for a few minutes after baking to help it set.

Substitutes and Variations

• Use turkey instead of chicken – Perfect for post-holiday leftovers.
• Swap cream cheese for Greek yogurt – For a slightly tangier and healthier option.
• Use a different cheese blend – Try Monterey Jack, Gouda, or Colby Jack.

Nutritional Breakdown

Nutrient	Amount per Serving
Calories	480
Protein	28g
Carbs	45g
Fat	20g
Fiber	3g

What Others Are Saying About The Recipe

Catalina D.: “This casserole has become my go-to comfort meal. My kids usually turn their noses up at anything with tomatoes, but they devoured this! I’ll definitely be making it again.”

Khalid G.: “Brought this to my friend’s game night, and let’s just say there were no leftovers. Someone even asked if I secretly ordered it from a restaurant! Cheesy, creamy, and so satisfying.”

Emilia P.: “I love how simple this was to throw together. I added a handful of crispy bacon bits, and wow!!! Next-level goodness! Perfect for a cozy weeknight meal.”

FAQs

Can I make this casserole ahead of time?

Yes! Assemble the casserole and refrigerate it for up to 24 hours before baking.

What can I use instead of cream of mushroom soup?

You can substitute it with another can of cream of chicken or homemade mushroom sauce.

Can I use gluten-free pasta?

Absolutely! Just ensure you don’t overcook it, as gluten-free pasta can be more fragile.

Final Thoughts

I know firsthand how chaotic mealtime can get, and this casserole has saved me on more than one busy evening. If you give it a try, let me know how it turns out! Did you tweak the recipe or stick to the classic? Either way, I’d love to hear all about it!